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KMID : 0043320080310040468
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Archives of Pharmacal Research
2008 Volume.31 No. 4 p.468 ~ p.473
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Inhibition of Proliferation in Colon Cancer Cell Lines and Harmful Enzyme Activity of Colon Bacteria by Bifidobacterium adolescentis SPM0212
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Kim Yu-Na
Lee Do-Kyung
Kim Dong-Hyun
Cho Joo-Yong
Yang Jae-Wook
Chung Myung-Jun
Kim Kyung-Jae
Ha Nam-Joo
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Abstract
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In this study, we assessed the anticancer activity and bacterial enzyme inhibition of Bifidobacterium adolescentis SPM0212. B. adolescentis SPM0212 inhibited the proliferation of three human colon cancer cell lines: HT-29, SW 480, and Caco-2. SPM0212 also dose-dependently inhibited production and changes in cellular morphology. B. adolescentis SPM0212 inhibited harmful fecal enzymes, including , , tryptophanase, and urease. Thus, B. adolescentis SPM0212 exerts an anticancer effect and inhibits harmful fecal enzymes.
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KEYWORD
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Bifidobacterium adolescentis, Colon cancer, HT-29, SW 480, Caco-2, Bacterial enzyme in colon
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